Waters was well known for her animal paintings and primitive style. Most of her portraits included subjects with stylized postures and faces even though the settings of her paintings were often detailed.
Waters painted at least 28 portraits between 1843 and 1845. Despite these years of productivity, the demand for painted portraits decreased in the 1840s and 50s with the advent of photography in America. In addition to being a talented painter, Waters was also selected as the recording secretary of the New Jersey Women Suffrage Association in 1871.